[Paper] SURMOUNT-4 withdrawal arm, read the appendix not the abstract
Trying to settle this properly because the thread from last year went in circles.
The claim: FLOW matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 24 months without either producing anything.
What would actually settle it is 35 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
Yeah, absolute numbers matter more than the press release.
SELECT reported a TRIUMPH hazard ratio but the absolute event rate is what changes clinical practice.
SURMOUNT-4 discontinuation arm showed regain. That is the reality of a chronic disease treatment, not a failure.
STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix
The confident tone is doing a lot of work that the evidence is not.
No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.
number-needed-to-treat is the house dialect
Disagree. What you are describing is consistent with STEP, not with what you concluded.
dropout handling matters, especially on GI-heavy populations
This is the "correlation is mechanism" thing again. You changed three variables at once.
Not convinced. The evidence does not support that reading.
The confident tone is doing a lot of work that the evidence is not.
give the trial name, phase, n, and primary endpoint in the body
Which trial and what was the primary endpoint?
Is that absolute or relative risk reduction?
event rates are more informative than hazard ratios alone
event rates are more informative than hazard ratios alone
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
absolute risk reduction, not relative risk reduction, that is how you decide
Yeah, absolute numbers matter more than the press release.
- 1This is the "correlation is mechanism" thing again. You changed three…10 comments in this branch · started by u/hub_ops
- 2STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix6 comments in this branch · started by u/nightowl_injector