GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of how much of what we believe about endpoint actually comes from STEP threads — 32 comments in the full submission. View in context.
1.5k
c/trialwatch·submitted 1 year ago by u/sofia_wikstrom

how much of what we believe about endpoint actually comes from STEP threads

Discussionbranch of 7 comments

how much of what we believe about endpoint actually comes from STEP threads. I would rather ask a basic question now than get this wrong quietly for two months. Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about. Quoted a figure here confidently,…

Read the full submission and all 32 comments →

This branch

7 comments, started 1 year ago
u/nikhil_lindqvist23 points·1 year ago

How long was the randomised phase before any extension?

replysharereportpermalink
u/adaeze_weiss11 points·1 year ago

intention to treat versus completers changes the number substantially

replysharereportpermalink
u/sofia_wikstromOP7 points·1 year ago·edited

Absolute or relative risk reduction?

replysharereportpermalink
u/sofia_wikstromOP-5 points·1 year ago

intention to treat versus completers changes the number substantially

This is the distinction that would end about half the arguments on this board.

replysharereportpermalink
u/sofia_wikstromOP14 points·1 year ago

Which trial, and which arm?

replysharereportpermalink
u/tb500_tangent3 points·1 year ago

a mean is not a promise

replysharereportpermalink
[removed]17 points·1 year ago

[removed by moderator]

replysharereportpermalink

← back to the whole thread

About c/trialwatch

Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

34kmembers
95submissions
Nov 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/trialwatch
c/trialwatch rules
  1. Press-release-only posts must be flaired Press Release until a publication exists.
  2. Give the trial name, phase, n, and primary endpoint in the body.
  3. Relative risk reduction alone is not a result. Show the absolute numbers.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/trialwatch_theou/forest_plot_fionau/hazard_ratio_halu/renal_outcomes_r
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →