[Question] how do you actually verify SURPASS
how do you actually verify SURPASS — that is what I am asking, and I have already read the wiki twice. Started keeping the trial identifiers straight in a note file because I kept mixing up two programmes in the same sentence. Went looking for the registered protocol to see whether the endpoint had changed. It had…
A confidence interval is the range of effects compatible with the data. Two trials with overlapping intervals have not disagreed, whatever their point estimates look like next to each other.
Added the trial identifier to the title so this thread is findable in two years.
the confidence interval is the finding, the point estimate is the headline
SELECT was cardiovascular outcomes, not weight
How long was the randomised phase before any extension?
Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.
FLOW was kidney outcomes and it is the one nobody quotes
SURPASS is the diabetes programme and reports glycaemic endpoints
the appendix is where the interesting tables live
intention to treat versus completers changes the number substantially
Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.