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Single comment threadYou are looking at one branch of genuine question about TRIUMPH that I am slightly embarrassed to ask — 48 comments in the full submission. View in context.
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c/trialwatch·submitted 2 years ago by u/joaquin_trevino

genuine question about TRIUMPH that I am slightly embarrassed to ask

Trial Databranch of 9 comments

Trying to get a straight answer on this: genuine question about TRIUMPH that I am slightly embarrassed to ask. Why comparing across trials almost never works, with the specific failure modes. Different populations: an obesity programme and a diabetes programme enrol different people with different baseline…

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9 comments, started 2 years ago
u/anders_karlsen387 points·2 years ago

Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.

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u/cold_chromatogram31120 points·2 years ago

What did the confidence interval look like?

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u/tove_ogunleye56 points·2 years ago

the confidence interval is the finding, the point estimate is the headline

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u/joaquin_trevinoOP-8 points·2 years ago

the confidence interval is the finding, the point estimate is the headline

Agreed. And the interval, not the point estimate, is what the trial actually established.

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u/joaquin_trevinoOP0 points·2 years ago

Correcting myself upthread: I gave the completer figure and labelled it intention-to-treat.

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u/whois_wanda36 points·2 years ago

a mean is not a promise

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u/renal_outcomes_rnephro-curious8 points·2 years ago

trial populations get support that nobody on this board gets

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u/ferran_dahlberg202 points·2 years ago

Careful with that mean. The distribution around it was wide enough that it describes very few individual participants.

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