the STEP thing finally clicked for me and I want to write it down
the STEP thing finally clicked for me and I want to write it down. Change my mind, genuinely — I have no stake in being right about this. On means, which this board treats as targets and which are nothing of the sort. A reported mean body weight change is the centre of a distribution that in these trials is very…
The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.
That is the 68-week readout, not the 72-week one. Different trial, different duration.
Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.
Right — trial participants get structured support. Comparing yourself to a trial mean is comparing across two different interventions.
Right — trial participants get structured support.
This is the distinction that would end about half the arguments on this board.