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c/trialwatch·submitted 6 months ago by u/nordic_pricing

someone explain FLOW to me like I have not read a paper in years

Discussionbranch of 7 comments

someone explain FLOW to me like I have not read a paper in years. Searched first, found three threads that contradict each other, hence the post. The discontinuation numbers were the most useful thing in the paper for me and they were in a supplementary table. Compared myself to a trial mean for about six months…

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7 comments, started 6 months ago
u/cesar_ivaturi360 points·6 months ago

Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.

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u/hazard_ratio_halMOD213 points·6 months ago

Added the trial identifier to the title so this thread is findable in two years.

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u/iman_castellanos400 points·6 months ago

trial populations get support that nobody on this board gets

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u/nhs_waitlist_nUK142 points·6 months ago

trial populations get support that nobody on this board gets

Disagreeing with this line: that is a relative reduction and the absolute numbers are considerably less dramatic.

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u/receipts_or_nothingvetting77 points·6 months ago

Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.

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u/ewan_tulloch72 points·6 months ago

STEP is semaglutide obesity, SURMOUNT is tirzepatide obesity, they are not interchangeable

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u/zaid_roos59 points·6 months ago·edited

Correction: SURMOUNT is the obesity programme and SURPASS is the diabetes one. The figure you quoted belongs to the other one.

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