how much of what we believe about endpoint actually comes from SURMOUNT threads
how much of what we believe about endpoint actually comes from SURMOUNT threads. I am not trying to be the "source?" guy. I would just like a source. How to read one of these papers in fifteen minutes, in the order that actually helps. Start with the registered protocol and check the primary endpoint against what is…
Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.
the appendix is where the interesting tables live
Cardiovascular outcome trials are powered for events, not for weight, and are typically run in a different population with different inclusion criteria. Reading a weight number out of one is reading a secondary endpoint.
Compared myself to a trial mean for about six months before realising the trial arm had dietitian contact every fortnight.
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The discontinuation numbers were the most useful thing in the paper for me and they were in a supplementary table.
Read a press release and the publication three months apart. The hedging in the second one was substantial.
This. Intention-to-treat versus completer analysis routinely moves the headline by several points.