does SELECT actually matter or is it forum lore at this point
The title is the whole question — does SELECT actually matter or is it forum lore at this point — but here is why I am asking. Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking. Started keeping the trial identifiers straight in a note…
Yes — the interval is the finding. A point estimate with a wide interval is a hypothesis in a nice font.
Retitled: the original quoted a diabetes endpoint as an obesity result.
Small fix — that was the cardiovascular outcomes trial, so weight was a secondary endpoint and the population was different.
FLOW was kidney outcomes and it is the one nobody quotes
This. Intention-to-treat versus completer analysis routinely moves the headline by several points.
What did the confidence interval look like?
Retitled: the original quoted a diabetes endpoint as an obesity result.
hazard_ratio_hal is right about the programme names. They are different populations with different endpoints.
Do you have the publication or the press release?
That is the 68-week readout, not the 72-week one. Different trial, different duration.