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c/trialwatch·posted 23 days ago by u/renal_outcomes_r

watch where the curves separate, not just whether they do

Paper Slow Clap ×9

Week 19 update. 10kg down from the start, early fullness basically gone since about week 71.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with early fullness.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

449 up / 86 down84% upvoted19 commentsid 11fwwj7 Jul 2026

19 comments

12 in this archive, depth 4

best — the order this archive was captured in

u/rina_bergstrom22 points·22 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

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u/milos_vanhecke11 points·22 days ago

absolute risk reduction, not relative risk reduction, that is how you decide

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/naomi_ekstrom4 points·22 days ago

STEP, SURMOUNT, SURPASS, SELECT, FLOW, TRIUMPH — read the appendix

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u/adaeze_cabrera17 points·22 days ago

This is correct. Discontinuation arms show the regain reality.

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u/milos_vanhecke13 points·22 days ago·edited

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/yara_mensah5 points·21 days ago

press release SELECT posts must be flaired until a publication exists

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u/first_hundred2 points·21 days ago

Not convinced. The evidence does not support that reading.

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u/curious_panel_only4 points·21 days ago

give the trial name, phase, n, and primary endpoint in the body

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u/renal_outcomes_rnephro-curious5 points·20 days ago

press release TRIUMPH posts must be flaired until a publication exists

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u/forest_plot_fionaMOD6 points·21 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/hugo_norgaard7 points·20 days ago

Strongly agree. Phase 2 is investigational, not conclusive.

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u/bastian_ekstrom4 points·21 days ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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Clinical trial reading group. New readouts, protocol amendments, endpoint definitions, dropout handling, and the difference between a press release and a publication. Absolute risk reduction and number-needed-to-treat are house dialect here.

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