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c/trialwatch·posted 1 months ago by u/yara_mensah

SURPASS — 10 things I got wrong before I got it right

Press Release

Thinking out loud about this: SURPASS — 10 things I got wrong before I got it right.

Started keeping the trial identifiers straight in a note file because I kept mixing up two programmes in the same sentence.

Went looking for the registered protocol to see whether the endpoint had changed. It had not, which was reassuring and worth checking.

The discontinuation numbers were the most useful thing in the paper for me and they were in a supplementary table.

Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.

87 up / 134 down39% upvoted11 commentsid 10ly3h26 Jun 2026

11 comments

11 in this archive, depth 5

best — the order this archive was captured in

u/nils_tulloch16 points·1 months ago·edited

Relative risk reduction without the baseline rate is uninterpretable. A large relative reduction on a small absolute risk is a small absolute benefit.

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u/renal_outcomes_rnephro-curious-28 points·1 months ago

read the endpoint before you read the headline

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u/nhs_waitlist_nUK1 point·1 months ago

The registered protocol is public. Comparing the registered primary endpoint with the reported one is a two-minute check and it is how outcome switching gets caught.

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u/cesar_ivaturi-39 points·1 months ago

Argued for a week about a result and then read the limitations section, which conceded most of my opponent’s point.

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u/yara_mensahOP1 point·1 months ago

a mean is not a promise

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u/whois_wanda1 point·1 months ago

Quoted a figure here confidently, got asked whether it was ITT, went and checked, and it was not. Learned something.

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u/iman_castellanos1 point·1 months ago

STEP is semaglutide obesity, SURMOUNT is tirzepatide obesity, they are not interchangeable

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u/bastian_ekstrom1 point·1 months ago

FLOW was kidney outcomes and it is the one nobody quotes

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u/piotr_bruun10 points·1 months ago

Compared myself to a trial mean for about six months before realising the trial arm had dietitian contact every fortnight.

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u/yara_mensahOP15 points·1 months ago

What did the confidence interval look like?

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u/tb500_tangent7 points·1 months ago

Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about.

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