how much of what we believe about endpoint actually comes from TRIUMPH threads
how much of what we believe about endpoint actually comes from TRIUMPH threads. I would rather ask a basic question now than get this wrong quietly for two months. Spent an evening with the appendix tables and found the subgroup detail that the entire thread had been speculating about. Quoted a figure here…
the appendix is where the interesting tables live
That is a relative risk reduction. Quoting it without the absolute numbers overstates the case considerably.
Relative risk reduction without the baseline rate is uninterpretable. A large relative reduction on a small absolute risk is a small absolute benefit.
Cosigning on discontinuation. It is a result about tolerability and it gets buried every time.
open-label extensions are not the same evidence as the randomised phase
Right — trial participants get structured support. Comparing yourself to a trial mean is comparing across two different interventions.
Open-label extensions lose their randomisation. Anybody still enrolled at week 104 is a selected group and the numbers describe that group.
a press release is not a publication