[Results] 47 weeks, 15kg, and GIP was the hard part
47 weeks, 15kg, and GIP was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted.
Since the title puts numbers in the shop window: 47 weeks and 15kg.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
the fatigue profile is genuinely gentler than people expect coming from sema
the appetite effect is blunter than sema, in a good way, most weeks
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
What is the waist doing? That is usually the number still moving during a scale stall.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Correction to my own post above — I said 7.5mg and I have been on 5mg since the spring. Same argument, wrong number.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
21kg over 82 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Pen or vial? The step sizes available differ and it changes this answer.
Came off sema and onto tirz with a two-week gap.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Did you come to this from sema, and if so how long was the gap?
- 1Switching from semaglutide, since three people asked in this thread alone.…7 comments in this branch · started by u/tidy_vialdrawer_pls
- 2stepping every four weeks is a ceiling on speed, not a schedule you must hit6 comments in this branch · started by u/laila_wikstrom