[Discussion] we are measuring Mounjaro at the wrong time and calling it noise
we are measuring Mounjaro at the wrong time and calling it noise — a position I have arrived at slowly and would like tested. On comparing yourself with the trial number. SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted…
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 51 is not a fair reading.
2.5 is the starter dose and it is not meant to be the dose that works
2.5 is the starter dose and it is not meant to be the dose that works
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
This.
Saving this one. It is the clearest statement of the stall problem I have read here.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Correction to my own post above — I said 7.5mg and I have been on 5mg since the spring. Same argument, wrong number.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
34kg over 83 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
the four-week step schedule is the label, not folklore
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
the four-week step schedule is the label, not folklore
ignacio_vanhecke is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.