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c/tirzepatide·submitted 1 year ago by u/kaia_wojcik

how much of what we believe about dual agonist actually comes from GIP threads

Side Effectsbranch of 6 comments

The title is the whole question — how much of what we believe about dual agonist actually comes from GIP threads — but here is why I am asking. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the…

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6 comments, started 1 year ago
u/thyroid_tangent128 points·1 year ago·edited

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/kaia_wojcikOP96 points·1 year ago

Not sure that follows.

Saving this one. It is the clearest statement of the stall problem I have read here.

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u/bastian_eriksen0 points·1 year ago

Saving this one.

kaia_wojcik is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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[deleted]1 point·1 year ago

[deleted]

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u/dario_vermeulen70 points·1 year ago

What step are you on and how long have you been there?

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u/quiet_moderatormod104 points·1 year ago

switching from sema is not a dose conversion, there is no clean equivalence

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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