how much of what we believe about dual agonist actually comes from GIP threads
The title is the whole question — how much of what we believe about dual agonist actually comes from GIP threads — but here is why I am asking.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
23kg over 69 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
week 5 is early to draw any conclusion at all
week 5 is early to draw any conclusion at all
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Which week did the appetite change actually land for you?
Have you held a step for longer than the four-week minimum at any point?
Did you come to this from sema, and if so how long was the gap?
Correction to my own post above — I said 10mg and I have been on 15mg since the spring. Same argument, wrong number.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
the muscle cramps profile is genuinely gentler than people expect coming from sema
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Not sure that follows.
Saving this one. It is the clearest statement of the stall problem I have read here.
Saving this one.
kaia_wojcik is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
What step are you on and how long have you been there?
switching from sema is not a dose conversion, there is no clean equivalence
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
hold the dose that works, the ladder is not a leaderboard
hold the dose that works, the ladder is not a leaderboard
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
What is the waist doing? That is usually the number still moving during a scale stall.
2.5 is the starter dose and it is not meant to be the dose that works
stepping every four weeks is a ceiling on speed, not a schedule you must hit
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
- 1Appetite effect for me is flat across seven days. On sema it was a wave.…7 comments in this branch · started by u/mikkel_ogunleye
- 2Not sure that follows. You went up a step and changed your training in the…6 comments in this branch · started by u/thyroid_tangent