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Single comment threadYou are looking at one branch of genuine question about tirzepatide that I am slightly embarrassed to ask — 65 comments in the full submission. View in context.
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c/tirzepatide·submitted 1 year ago by u/throwaway_wl2026

genuine question about tirzepatide that I am slightly embarrassed to ask

Trial Databranch of 8 comments

genuine question about tirzepatide that I am slightly embarrassed to ask. If this has been answered properly somewhere, link me and I will delete. Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.…

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This branch

8 comments, started 1 year ago
u/quiet_moderatorMOD89 points·1 year ago

Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.

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u/laila_yilmaz71 points·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/aksel_kjaer59 points·1 year ago

if 7.5 is working, 10 is not automatically better

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u/blunt_coldbox2917 points·1 year ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/aurel_lindqvist8 points·1 year ago

switching from sema is not a dose conversion, there is no clean equivalence

blunt_coldbox29 is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/crosspost_bot_no59 points·1 year ago

sulphur burps are the signature complaint and they are not dangerous

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u/ghrp_history68 points·1 year ago

Switching from semaglutide, since three people asked in this thread alone.

There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.

None of that is a recommendation. It is what the threads say, and the threads are not a clinic.

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u/copay_card_cc17 points·1 year ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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