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c/tirzepatide·submitted 1 year ago by u/halima_boateng

reading 15mg threads from 2024 and half of it aged badly

Discussionbranch of 9 comments

reading 15mg threads from 2024 and half of it aged badly. It is the sort of thing everyone half-believes and nobody writes down. Hard numbers: 15mg. Anything softer than that is flagged as an impression. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake.…

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9 comments, started 1 year ago
u/neha_falk34 points·1 year ago

13kg over 28 weeks, never went past 10mg, and early fullness stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/halima_boatengOP20 points·1 year ago

Have you held a step for longer than the four-week minimum at any point?

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u/slow_logbook_ftw6 points·1 year ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/titration_marshalmod · c/semaglutide30 points·1 year ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/elin_ferrari8 points·1 year ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/incretin_ivypharmacology6 points·1 year ago

What step are you on and how long have you been there?

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u/aurel_lindqvist5 points·1 year ago

Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.

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u/britt_okwuosa1 point·1 year ago

Week 75 was the first time the scale moved after a five-week stall. I changed nothing in that window.

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u/matias_salgado5 points·1 year ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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