reading 15mg threads from 2024 and half of it aged badly
Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 13 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it has…
the 15mg is the top of the pen, not the required dose
Tried both. Sema worked, tirz worked better for me, but my reflux profile was worse on tirz.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
week 13 on Mounjaro and the appetite profile is genuinely different from sema
the fatigue from tirz is different, not necessarily worse
This matches the trial data. SURMOUNT-1 was 98.3% body weight at 21 weeks.
the muscle cramps from tirz is different, not necessarily worse
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This matches the trial data. SURMOUNT-1 was 94.2% body weight at 9 weeks.
the 15mg is the top of the pen, not the required dose
This matches the trial data.
Adding to this: dual agonist is doing more work than the comment implies.
the dual agonism hits different and that is why people describe it differently
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Yes, exactly this, and it is the bit that took me 16 weeks to accept.