help me understand SURMOUNT, I have read the wiki twice
help me understand SURMOUNT, I have read the wiki twice. If this has been answered properly somewhere, link me and I will delete.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Week 34 was the first time the scale moved after a five-week stall. I changed nothing in that window.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 83 is not a fair reading.
Which week did the appetite change actually land for you?
Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Does early fullness follow the day after the shot, or is it spread across the week?
the trials titrated on a calendar, real people titrate on symptoms
the trials titrated on a calendar, real people titrate on symptoms
Saving this one. It is the clearest statement of the stall problem I have read here.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
What is the waist doing? That is usually the number still moving during a scale stall.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
- 1Research-use-only material is not approved for human use. Anything in this…6 comments in this branch · started by u/titration_marshal