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c/tirzepatide·submitted 1 year ago by u/emil_wojcik

someone explain 15mg to me like I have not read a paper in years

Titrationbranch of 16 comments

someone explain 15mg to me like I have not read a paper in years — that is what I am asking, and I have already read the wiki twice. Hard numbers: 15mg. Anything softer than that is flagged as an impression. The distribution matters more than the mean. In the trial population the interquartile spread was wide enough…

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16 comments, started 1 year ago
u/quiet_moderatorMOD237 points·1 year ago

This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.

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u/sanne_novak330 points·1 year ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/emil_wojcik274 points·1 year ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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[deleted]176 points·1 year ago

[deleted]

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u/kian_ekstrom-9 points·1 year ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/graph_it_gary163 points·1 year ago

23kg over 58 weeks, never went past 10mg, and muscle cramps stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/emil_wojcik196 points·1 year ago

the four-week step schedule is the label, not folklore

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u/emil_wojcikOP150 points·1 year ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/gentle_correctionnice about it0 points·1 year ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

emil_wojcik is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/dario_stanescu93 points·1 year ago

Have you held a step for longer than the four-week minimum at any point?

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u/emil_wojcikOP37 points·1 year ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/ahmed_iyer58 points·1 year ago

a lot of people plateau nicely at 10mg and never need 15

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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