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c/tirzepatide·submitted 1 year ago by u/crosspost_bot_no

[PSA] GIP is not what most of this community thinks it is

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Explainer, as requested in the last thread: GIP is not what most of this community thinks it is. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. The four-week interval in the label is a minimum.…

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6 comments, started 1 year ago
u/britt_okwuosa428 points·1 year ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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[deleted]301 points·1 year ago

[deleted]

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u/gustav_vermeulen111 points·1 year ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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u/ewan_marchand206 points·1 year ago

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/nz_unfunded332 points·1 year ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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