[PSA] GIP is not what most of this community thinks it is
Explainer, as requested in the last thread: GIP is not what most of this community thinks it is.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.
best — the order this archive was captured in
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
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Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
Do sulphur burps follow the day after the shot, or is it spread across the week?
Do sulphur burps follow the day after the shot, or is it spread across the week?
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
29kg over 94 weeks, never went past 10mg, and food noise stayed mild the whole way. Posting because the loud threads are all 15mg.
Which week did the appetite change actually land for you?
2.5 is the starter dose and it is not meant to be the dose that works
Not sure that follows. You went up a step and changed your training in the same fortnight.
Did you come to this from sema, and if so how long was the gap?
sulphur burps are the signature complaint and they are not dangerous
the trials titrated on a calendar, real people titrate on symptoms
the trials titrated on a calendar, real people titrate on symptoms
Saving this one. It is the clearest statement of the stall problem I have read here.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 10 is not a fair reading.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
if 7.5 is working, 10 is not automatically better
the four-week step schedule is the label, not folklore
a lot of people plateau nicely at 10mg and never need 15
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
hold the dose that works, the ladder is not a leaderboard
hold the dose that works, the ladder is not a leaderboard
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
What is the waist doing? That is usually the number still moving during a scale stall.
the appetite effect is blunter than sema, in a good way, most weeks
the appetite effect is blunter than sema, in a good way, most weeks
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
- 1Not sure that follows. You went up a step and changed your training in the…11 comments in this branch · started by u/kaia_cabrera
- 2Weekly dosing again, half-life in the same neighbourhood as sema, so a step…6 comments in this branch · started by u/britt_okwuosa