what would you tell week-1 you about GIP
Trying to get a straight answer on this: what would you tell week-1 you about GIP.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.
best — the order this archive was captured in
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
Saving this one. It is the clearest statement of the stall problem I have read here.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
quiet_moderator is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Correction to my own post above — I said 15mg and I have been on 2.5mg since the spring. Same argument, wrong number.
Correction to my own post above — I said 15mg and I have been on 2.5mg since the spring.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
week 10 is early to draw any conclusion at all
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
Not sure that follows. You went up a step and changed your training in the same fortnight.
What is the waist doing? That is usually the number still moving during a scale stall.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
Did you come to this from sema, and if so how long was the gap?
the trials titrated on a calendar, real people titrate on symptoms
SURMOUNT-1 landed around 21% at 72 weeks on the top arm
the early fullness profile is genuinely gentler than people expect coming from sema
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sulphur burps are the signature complaint and they are not dangerous
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