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c/tirzepatide·posted 4 days ago by u/nightowl_injector

[Log] eight weeks in, here’s the actual schedule and what each step felt like

Discussion Cold Box ×5

Posting the boring version of a titration log because I wish I'd had one with this much unremarkable detail before I started.

Weeks 1–4: starter dose, mild fatigue day 1–2 after each shot, otherwise nothing notable. Weeks 5–8: first step up, some appetite change finally noticeable around day 10, one rough weekend of GI stuff that passed on its own.

Not a recommendation for anyone else's schedule, just what mine looked like, Sunday 8pm every week, in case the granular version is useful to someone deciding whether to panic.

494 up / 120 down80% upvoted18 commentsid ovw70t26 Jul 2026

18 comments

14 in this archive, depth 3

best — the order this archive was captured in

u/sunday_shot_sal143 points·3 days ago

Sunday 8pm gang. 61 weeks straight here and the consistency of the day/time matters more than people think, it turns it into a non-decision instead of a daily debate.

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u/nightowl_injectorOP68 points·3 days ago

same logic for me, evening also means I sleep through the worst of the first-day fatigue

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u/insulin_syringe_ian41 points·3 days ago

evening dosing + sleeping through the peak side effect window is genuinely underrated advice

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u/dose_diary_danalog keeper89 points·4 days ago

78 weeks into my own public log and the pattern you're describing (nothing week 1-4, mild something week 5-8) is close to the median shape I've seen reported. Useful that you're logging it plainly instead of dramatizing it.

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u/week_one_wanda52 points·3 days ago

reading this at day 6 of my own starter dose and it's calming me down a normal amount, thank you

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u/nightowl_injectorOP29 points·3 days ago

that's genuinely why I posted it, glad it's doing that job

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u/first_pen_fear24 points·4 days ago

the "mild fatigue day 1-2" thing matches exactly what I've got at week 3, was starting to worry it meant something

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[deleted]2 points·3 days ago

[deleted]

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u/insulin_syringe_ian33 points·3 days ago

U-100, 31g, 8mm, 0.3mL over here, always worth restating for anyone reading a log post and eyeballing their own syringe for the first time

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u/anecdata_annie21 points·3 days ago

one log is one data point, that said this is a genuinely useful one data point, the specificity is what makes it useful

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u/graph_it_gary18 points·4 days ago

would love to see this as a rolling-average chart once you're further in, raw weekly numbers on a titration log tend to hide the trend under the noise

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u/nightowl_injectorOP12 points·3 days ago

noted, starting a proper spreadsheet from week 9 onward, this comment section talked me into it

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u/quiet_reader_999 points·3 days ago

saving this thread, mostly for the "not a recommendation for anyone else" line, more logs should say that up front

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u/sorted_by_new7 points·4 days ago

caught this at 20 minutes old, log posts are the best thing to catch fresh honestly

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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