someone explain dual agonist to me like I have not read a paper in years
Genuine question, and the title is the question: someone explain dual agonist to me like I have not read a paper in years. Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved. Held 7.5 for five months. Everyone kept asking when I was going…
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
the trials titrated on a calendar, real people titrate on symptoms
the trials titrated on a calendar, real people titrate on symptoms
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
the appetite effect is blunter than sema, in a good way, most weeks
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 49 is not a fair reading.