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Single comment threadYou are looking at one branch of the nausea profile at 7.5 was worse than 10 for me and i cannot explain it — 54 comments in the full submission. View in context.
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c/tirzepatide·submitted 13 days ago by u/hana_pereira

the nausea profile at 7.5 was worse than 10 for me and i cannot explain it

Trial Databranch of 6 comments

Genuinely asking, not being difficult. Everyone in c/bloodwork repeats that GIP is important. I believe it, but I have never seen anyone show why, and when I search I get 10 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it has…

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6 comments, started 12 days ago
u/quiet_moderatorMOD306 points·12 days ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/fatima_wojcik131 points·12 days ago·edited

Not convinced. The evidence does not support that reading.

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u/emil_wojcik177 points·12 days ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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[deleted]121 points·11 days ago

[deleted]

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u/discount_math_dm206 points·12 days ago

Respectfully this is a sample of one presented as a finding.

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u/curious_panel_only49 points·12 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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