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c/tirzepatide·posted 9 months ago by u/piotr_nascimento

[Lab] 8th independent test on QST — 98.6% on a claimed 98.5%, and the trend is the interesting part

Lab Receipts ×1 Slow Clap ×2

8th independent test on QST — 98.6% on a claimed 98.5%, and the trend is the interesting part. I will put the method line and the batch identifier up front because that is what makes this checkable.

The relevant figures are 98.6% and 98.5%, and they come from the same log I have kept the whole time.

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

2,058 up / 713 down74% upvoted37 commentsid nkz32o30 Oct 2025
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37 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/mikkel_kimani263 points·9 months ago·edited

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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[deleted]104 points·9 months ago

[deleted]

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u/forest_plot_fionastats-18 points·9 months ago

Same experience with the appetite effect being flatter across the week rather than front-loaded.

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u/incretin_ivypharmacology-27 points·9 months ago

pens and vials are the same molecule, the price is the difference

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u/aksel_kjaer1 point·9 months ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/cato_girard144 points·9 months ago·edited

Careful with "everyone tolerates it better". The people it did not suit stop posting, which makes this board look calmer than the drug is.

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u/endpoint_creep50 points·9 months ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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u/britt_okwuosa95 points·9 months ago

if 7.5 is working, 10 is not automatically better

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u/line_petrov67 points·9 months ago·edited

Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.

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u/search_before_post79 points·9 months ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/ingrid_correia33 points·9 months ago

I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your sulphur burps pattern is a guess.

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u/aksel_kjaer20 points·9 months ago

Did you come to this from sema, and if so how long was the gap?

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u/ferran_mensah24 points·9 months ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/piotr_nascimento54 points·9 months ago

Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.

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u/rania_marchand45 points·9 months ago

stepping every four weeks is a ceiling on speed, not a schedule you must hit

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u/piotr_nascimentoOP27 points·9 months ago

Pen or vial? The step sizes available differ and it changes this answer.

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u/halima_boateng40 points·9 months ago

The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.

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u/titration_marshalmod · c/semaglutide19 points·9 months ago

Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.

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