is it normal to get food noise at week 85
Reporting in. is it normal to get food noise at week 85.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
hold the dose that works, the ladder is not a leaderboard
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
What step are you on and how long have you been there?
This is the fifth "should I go up" post today and they are all welcome — but no member here can answer it for you.
sulphur burps are the signature complaint and they are not dangerous
22kg over 77 weeks, never went past 10mg, and early fullness stayed mild the whole way. Posting because the loud threads are all 15mg.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Did you come to this from sema, and if so how long was the gap?
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
The step schedule question, answered properly, because it comes up weekly.
The label sets a minimum interval of four weeks between increases. That is a floor on how fast you may go, and it exists because tolerability, not efficacy, is what limits most people. There is nothing in the pharmacology that says you must increase at four weeks, or at eight, or ever.
What decides it in practice is whether the effect you want is still there. If appetite is quiet and the trend is going the right way, the dose is doing its job. If both have genuinely gone flat for six weeks or more, that is a conversation worth having with someone who knows your history.
What is the waist doing? That is usually the number still moving during a scale stall.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
What is the waist doing?
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
- 1It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part…7 comments in this branch · started by u/forest_plot_fiona