[PSA] Zepbound is not what most of this community thinks it is
Putting this at the top of the board where it belongs: Zepbound is not what most of this community thinks it is. The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to. Vials and pens carry the same…
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
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Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
sulphur burps are the signature complaint and they are not dangerous
Did you come to this from sema, and if so how long was the gap?
Week 27 was the first time the scale moved after a five-week stall. I changed nothing in that window.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.