[Results] 45 weeks, 14kg, and tirzepatide was the hard part
45 weeks, 14kg, and tirzepatide was the hard part, logged the same way every week so the comparison is at least internally fair.
The numbers the title promised, since a headline without them is worthless: 45 weeks and 14kg. Everything below is context for those.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
best — the order this archive was captured in
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
7kg over 18 weeks, never went past 10mg, and early fullness stayed mild the whole way. Posting because the loud threads are all 15mg.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
the constipation profile is genuinely gentler than people expect coming from sema
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
switching from sema is not a dose conversion, there is no clean equivalence
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
Week 54 was the first time the scale moved after a five-week stall. I changed nothing in that window.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Correction to my own post above — I said 10mg and I have been on 12.5mg since the spring. Same argument, wrong number.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
sulphur burps are the signature complaint and they are not dangerous
hold the dose that works, the ladder is not a leaderboard
week 10 is early to draw any conclusion at all
Not sure that follows. You went up a step and changed your training in the same fortnight.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
zepbound and mounjaro are the same compound with different labels
2.5 is the starter dose and it is not meant to be the dose that works
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
- 1stepping every four weeks is a ceiling on speed, not a schedule you must hit9 comments in this branch · started by u/marta_dziedzic
- 2Sulphur burps for the first eight days after each step, then nothing.…8 comments in this branch · started by u/rania_marchand