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c/tirzepatide·submitted 3 months ago by u/mikkel_ogunleye

unpopular opinion: most of what gets said here about 15mg is guesswork

Titrationbranch of 6 comments

unpopular opinion: most of what gets said here about 15mg is guesswork, and I am aware this is a minority view on this board. 15mg. Those are measured, not estimated, and not rounded up in my favour. 32kg over 66 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the…

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6 comments, started 3 months ago
u/samir_falk43 points·3 months ago

Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.

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u/mikkel_ogunleye-26 points·3 months ago

the appetite effect is blunter than sema, in a good way, most weeks

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u/bastian_ekstrom1 point·3 months ago

Are you comparing yourself with the trial mean or with the people who post the most?

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[removed]1 point·3 months ago

[removed by moderator]

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u/mikkel_ogunleyeOP1 point·3 months ago

Which week did the appetite change actually land for you?

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u/copay_card_cc1 point·3 months ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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