unpopular opinion: most of what gets said here about 15mg is guesswork
unpopular opinion: most of what gets said here about 15mg is guesswork, and I am aware this is a minority view on this board. 15mg. Those are measured, not estimated, and not rounded up in my favour. 32kg over 66 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the…
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 33 is not a fair reading.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your reflux pattern is a guess.