[Results] 67 weeks, 10kg, and dual agonist was the hard part
67 weeks, 10kg, and dual agonist was the hard part, and the part I actually want to talk about is at the bottom.
To save the first four comments: 67 weeks and 10kg.
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
28kg over 59 weeks, never went past 10mg, and nausea stayed mild the whole way. Posting because the loud threads are all 15mg.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Reminder that nobody in this thread is your clinician and the sidebar says so for a reason.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
Which week did the appetite change actually land for you?
the trials titrated on a calendar, real people titrate on symptoms
Does reflux follow the day after the shot, or is it spread across the week?
a lot of people plateau nicely at 10mg and never need 15
hold the dose that works, the ladder is not a leaderboard
What is the waist doing? That is usually the number still moving during a scale stall.
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 50 is not a fair reading.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
The four-week interval in the label is a minimum.
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about