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c/tirzepatide·submitted 2 months ago by u/two_mil_or_one

small win: Mounjaro stopped being a problem at week 45

Questionbranch of 9 comments

small win: Mounjaro stopped being a problem at week 45. This is a description of what happened to me and not a plan for anybody else. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. The four-week…

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9 comments, started 2 months ago
u/fatima_wojcik6 points·2 months ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/emil_wojcik1 point·2 months ago·edited

SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.

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u/two_mil_or_oneOP1 point·2 months ago

Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.

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u/forest_plot_fionastats1 point·2 months ago

Have you held a step for longer than the four-week minimum at any point?

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u/bastian_ekstrom0 points·2 months ago

Have you held a step for longer than the four-week minimum at any point?

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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[deleted]2 points·2 months ago

[deleted]

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u/two_mil_or_oneOP1 point·2 months ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/samir_falk0 points·2 months ago

Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.

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u/endpoint_creep2 points·2 months ago

zepbound and mounjaro are the same compound with different labels

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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