nobody warned me about muscle cramps and I would have liked the warning
nobody warned me about muscle cramps and I would have liked the warning. Change my mind, genuinely — I have no stake in being right about this.
Switching from semaglutide, since three people asked in this thread alone.
There is no published dose equivalence between the two. The conversion tables that circulate are somebody’s arithmetic, not data. What people report here is that the first month after a switch is often flat, that the appetite effect feels differently shaped rather than simply stronger, and that starting at the bottom of the ladder again is the common approach.
None of that is a recommendation. It is what the threads say, and the threads are not a clinic.
Week 64 was the first time the scale moved after a five-week stall. I changed nothing in that window.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The four-week interval in the label is a minimum.
Saving this one. It is the clearest statement of the stall problem I have read here.
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2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
pens and vials are the same molecule, the price is the difference
The 21% figure is a 72-week mean on the highest arm. Quoting it as what someone should expect by week 30 is not a fair reading.
What step are you on and how long have you been there?
Not sure that follows. You went up a step and changed your training in the same fortnight.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your early fullness pattern is a guess.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Sulphur burps for the first eight days after each step, then nothing.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Sulphur burps for the first eight days after each step, then nothing.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Correction to my own post above — I said 12.5mg and I have been on 10mg since the spring. Same argument, wrong number.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
week 3 is early to draw any conclusion at all
Does food noise follow the day after the shot, or is it spread across the week?
Pen or vial? The step sizes available differ and it changes this answer.
the nausea profile is genuinely gentler than people expect coming from sema
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Have you held a step for longer than the four-week minimum at any point?
Have you held a step for longer than the four-week minimum at any point?
Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Are you comparing yourself with the trial mean or with the people who post the most?
Are you comparing yourself with the trial mean or with the people who post the most?
bastian_eriksen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
zepbound and mounjaro are the same compound with different labels
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
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