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c/tirzepatide·submitted 10 days ago by u/kaia_cabrera

[Discussion] "tirz is stronger than sema" needs a comparator dose or it means nothing

Discussionbranch of 6 comments

Been lurking in c/compounding for about 21 months and finally have something worth posting. Short version: week 53, 5mg, and GIP is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle. What I actually want to know is…

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6 comments, started 9 days ago
u/dexa_twice_yearlyMOD68 points·9 days ago

Tracking number removed. It identifies both ends of a shipment.

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u/slow_logbook_ftw45 points·9 days ago·edited

week 59 on Mounjaro and the appetite profile is genuinely different from sema

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u/kaia_cabreraOP-37 points·9 days ago

the GIP side does different things than the GLP-1 side, that is the point

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u/tove_vasquez13 points·9 days ago·edited

do not crack the pen, we have been over this

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u/slow_logbook_ftw37 points·9 days ago·edited

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/kaia_cabreraOP21 points·9 days ago

Week 25 on Mounjaro and 23kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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