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c/tirzepatide·submitted 7 days ago by u/emil_okwuosa

why is nobody talking about the SURPASS-CVOT readout

Labbranch of 6 comments

Asking properly rather than in a comment on somebody else’s thread: why is nobody talking about the SURPASS-CVOT readout. Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate. Held 7.5 for five months.…

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6 comments, started 6 days ago
u/b12_baseline46 points·6 days ago

Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.

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u/bastian_eriksen28 points·5 days ago

Research-use-only material is not approved for human use.

Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.

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u/zeynep_zielinski11 points·5 days ago

Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.

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u/thyroid_tangent4 points·5 days ago

pens and vials are the same molecule, the price is the difference

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[removed]20 points·5 days ago

[removed by moderator]

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u/coring_the_stopper23 points·5 days ago

Week 81 was the first time the scale moved after a five-week stall. I changed nothing in that window.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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