[Lab] SSA tirz 10mg — Janoshik 99.1%, third batch in a row
Genuinely asking, not being difficult.
Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 8 threads of people agreeing with each other.
Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?
I am not trying to be the "source?" guy. I would just like a source.
best — the order this archive was captured in
The confident tone is doing a lot of work that the evidence is not.
the GIP side does different things than the GLP-1 side, that is the point
Hard agree. The food noise disappears differently on the two compounds.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.
Yes, exactly this, and it is the bit that took me 78 weeks to accept.
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
I am going to push back on this slightly.
Retitled to remove editorialising. Put the evidence in the body.
Switched from sema at 12.5mg to tirz at 10mg. Different drugs, cannot compare the doses directly.
- 1the appetite change on tirz is more than just reduced hunger, it is…6 comments in this branch · started by u/hair_shed_hannah