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c/tirzepatide·posted 5 days ago by u/customs_seizure_sid

is the tirz appetite thing actually different or am i imagining it

Titration Cold Box ×4

Trying to settle this properly because the thread from last year went in circles.

The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 2 months without either producing anything.

What would actually settle it is 5 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

465 up / 98 down83% upvoted15 commentsid 1o23k725 Jul 2026

15 comments

7 in this archive, depth 2

best — the order this archive was captured in

u/noor_hovland31 points·4 days ago

Hard agree. The food noise disappears differently on the two compounds.

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u/hair_shed_hannah0 points·3 days ago

How long at each step before you escalated?

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u/hub_opssite staff19 points·4 days ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/dexa_twice_yearlyMOD13 points·3 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/discount_math_dm10 points·3 days ago

Switched from sema at 10mg to tirz at 7.5mg. Different drugs, cannot compare the doses directly.

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u/elin_ferrari12 points·3 days ago

Water content matters more than people think. If a vial is carrying residual moisture, your "10mg" is not 10mg of peptide.

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u/amara_halonen10 points·3 days ago

My ApoB moved faster on tirz than on sema at the same timepoint, which matches what people report.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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