[Meta] the SURPASS rule is doing its job and people should stop complaining
the SURPASS rule is doing its job and people should stop complaining, and here is what changes in practice if it goes ahead. SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category…
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
zepbound and mounjaro are the same compound with different labels
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
the appetite effect is blunter than sema, in a good way, most weeks
the appetite effect is blunter than sema, in a good way, most weeks
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
the four-week step schedule is the label, not folklore