[Lab] 22th independent test on WXT — 99.2% on a claimed 98.5%, and the trend is the interesting part
Posting this because the title is the whole finding — 22th independent test on WXT — 99.2% on a claimed 98.5%, and the trend is the interesting part — and a number without its method is a rumour.
The numbers the title promised, since a headline without them is worthless: 99.2% and 98.5%. Everything below is context for those.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.
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nofollow and sponsored; nobody here is paid for it.best — the order this archive was captured in
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
What is the waist doing? That is usually the number still moving during a scale stall.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Does reflux follow the day after the shot, or is it spread across the week?
a lot of people plateau nicely at 10mg and never need 15
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Pen or vial? The step sizes available differ and it changes this answer.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
On comparing yourself with the trial number.
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
sulphur burps are the signature complaint and they are not dangerous
week 6 is early to draw any conclusion at all
the sulphur burps profile is genuinely gentler than people expect coming from sema
the trials titrated on a calendar, real people titrate on symptoms
the four-week step schedule is the label, not folklore
Have you held a step for longer than the four-week minimum at any point?
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
dual agonist, so the GIP arm is doing something the sema threads will not tell you about
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
I would separate the two claims. That the GIP arm exists is uncontroversial; that it explains your sulphur burps pattern is a guess.
- 1the sulphur burps profile is genuinely gentler than people expect coming…8 comments in this branch · started by u/zaid_balogun