the Mounjaro thing finally clicked for me and I want to write it down
Something I keep coming back to: the Mounjaro thing finally clicked for me and I want to write it down.
Week 47 was the first time the scale moved after a five-week stall. I changed nothing in that window.
On comparing yourself with the trial number.
SURMOUNT-1 reported roughly 21% mean body weight change at 72 weeks on the highest arm. Three things get dropped every time that figure is quoted here. It is a mean, and the distribution around it is very wide. It is 72 weeks, which is a year and a half. And it is a trial population with trial support, which is not the same as a person with a spreadsheet.
Use it as a rough shape, not a benchmark. A 12% year is inside the ordinary range and people quit over it every week on this board.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
2.5 is the starter dose and it is not meant to be the dose that works
What is the waist doing? That is usually the number still moving during a scale stall.
Same experience with the appetite effect being flatter across the week rather than front-loaded.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
stepping every four weeks is a ceiling on speed, not a schedule you must hit
switching from sema is not a dose conversion, there is no clean equivalence
switching from sema is not a dose conversion, there is no clean equivalence
emil_wojcik is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
Not sure that follows. You went up a step and changed your training in the same fortnight.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
zepbound and mounjaro are the same compound with different labels
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Research-use-only material is not approved for human use.
This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
14kg over 59 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
if 7.5 is working, 10 is not automatically better
Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled.
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