anyone else notice GIP kicking in around week 81
anyone else notice GIP kicking in around week 81, logged the same way every week so the comparison is at least internally fair.
Sulphur burps for the first eight days after each step, then nothing. Predictable enough that I planned my week around it.
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.
best — the order this archive was captured in
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
Yes — 10mg being a genuine landing place for a lot of people is underrated. There is no medal for 15.
Left up, flair changed to Discussion. It is an opinion post and that is fine as long as it is labelled.
Have you held a step for longer than the four-week minimum at any point?
the appetite effect is blunter than sema, in a good way, most weeks
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Correction to my own post above — I said 2.5mg and I have been on 15mg since the spring. Same argument, wrong number.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
13kg over 42 weeks, never went past 10mg, and injection-site soreness stayed mild the whole way. Posting because the loud threads are all 15mg.
week 6 is early to draw any conclusion at all
week 6 is early to draw any conclusion at all
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.
the trials titrated on a calendar, real people titrate on symptoms
stepping every four weeks is a ceiling on speed, not a schedule you must hit
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
if 7.5 is working, 10 is not automatically better
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
2.5mg is a four-week starting dose, not a maintenance dose. Worth being precise since people search these threads.
- 1week 6 is early to draw any conclusion at all12 comments in this branch · started by u/quiet_moderator
- 2Yes — 10mg being a genuine landing place for a lot of people is underrated.…6 comments in this branch · started by u/cormac_pereira