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c/tirzepatide·submitted 2 years ago by u/piotr_nascimento

tirzepatide: the version I wish someone had shown me in week 1

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tirzepatide: the version I wish someone had shown me in week 1. This is a description of what happened to me and not a plan for anybody else. 20kg over 46 weeks, never went past 10mg, and constipation stayed mild the whole way. Posting because the loud threads are all 15mg. The distribution matters more than the…

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7 comments, started 2 years ago
u/incretin_ivyMOD306 points·2 years ago

Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.

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u/piotr_nascimentoOP196 points·2 years ago

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

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u/kian_ekstrom205 points·2 years ago

What step are you on and how long have you been there?

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u/blunt_coldbox2958 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/rania_marchand16 points·2 years ago

The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.

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[removed]11 points·2 years ago

[removed by moderator]

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u/ahmed_fonseca109 points·2 years ago

Not sure that follows. You went up a step and changed your training in the same fortnight.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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