[Meta] the tirzepatide rule is doing its job and people should stop complaining
the tirzepatide rule is doing its job and people should stop complaining, and it will stay as it is unless somebody makes the case to change it. The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have…
The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.
Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.
the appetite effect is blunter than sema, in a good way, most weeks
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.
zepbound and mounjaro are the same compound with different labels
2.5 is the starter dose and it is not meant to be the dose that works
What step are you on and how long have you been there?
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.