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c/tirzepatide·submitted 2 years ago by u/kian_ekstrom

am I the only one who found tirzepatide harder than the injections

Discussionbranch of 6 comments

am I the only one who found tirzepatide harder than the injections. I am not trying to be the "source?" guy. I would just like a source. The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to. Vials…

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6 comments, started 2 years ago
u/vito_chowdhury67 points·2 years ago

It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.

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u/throwaway_wl202619 points·2 years ago

a lot of people plateau nicely at 10mg and never need 15

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u/quiet_moderatormod5 points·2 years ago

the injection-site soreness profile is genuinely gentler than people expect coming from sema

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u/blunt_coldbox293 points·2 years ago·edited

Does injection-site soreness follow the day after the shot, or is it spread across the week?

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u/tarek_lokken7 points·2 years ago

This matches mine. Milder fatigue than I expected, and what there was settled inside a fortnight of each step.

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u/discount_math_dm6 points·2 years ago

Disagree with the conversion table. There is no validated equivalence between the two molecules and posting one as though there is does real damage.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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