unpopular opinion: most of what gets said here about GIP is guesswork
unpopular opinion: most of what gets said here about GIP is guesswork. Making the case below, and I expect to lose some of it in the comments.
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Weekly dosing again, half-life in the same neighbourhood as sema, so a step change takes about a month to reach steady state. Judging a new step at day five is judging noise.
It is a dual GIP and GLP-1 receptor agonist, and the GIP arm is the part that has no equivalent in the semaglutide threads. That is why the side-effect profile reads differently rather than just milder.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
Research-use-only material is not approved for human use. Anything in this thread about how a research vial "should" titrate is a discussion about chemistry, not a plan.
Pen or vial? The step sizes available differ and it changes this answer.
Agreed, and the trial number is a mean of a very wide distribution — the tails are enormous and nobody posts from the middle.
Removed the conversion table. There is no published equivalence between the two molecules and posting one as fact is exactly the kind of thing that gets copied for years.
the appetite effect is blunter than sema, in a good way, most weeks
2.5 is the starter dose and it is not meant to be the dose that works
Agree. The GIP component is the interesting half and it barely gets discussed outside c/glp1science.
What step are you on and how long have you been there?
What step are you on and how long have you been there?
Agreed, with one qualifier: that is the mean of the top arm and the spread around it was enormous.
Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.
Does early fullness follow the day after the shot, or is it spread across the week?
What is the waist doing? That is usually the number still moving during a scale stall.
Not sure that follows. You went up a step and changed your training in the same fortnight.
the constipation profile is genuinely gentler than people expect coming from sema
Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.
That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.
Cosigning the four-week thing. It is a minimum interval, and treating it as a schedule to keep up with is how people end up miserable at 12.5.
Yes. I stepped to 12.5 because the calendar said so, not because anything needed fixing, and I regretted it for a fortnight.
Held 7.5 for five months. Everyone kept asking when I was going to 10. The answer was never, because 7.5 was working.
Vials and pens carry the same molecule; what differs is fill volume, device tolerance and whether you are doing your own arithmetic. Neither is inherently more accurate.
Did you come to this from sema, and if so how long was the gap?
- 1the appetite effect is blunter than sema, in a good way, most weeks9 comments in this branch · started by u/sanne_novak
- 2Right. And the sema-to-tirz "conversion" people post is invented. There is…7 comments in this branch · started by u/vito_chowdhury