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c/tirzepatide·submitted 2 years ago by u/sten_palacios

week 16 check-in — 5kg down, reflux manageable, one thing confusing me

Questionbranch of 15 comments

Six-word version is the title — week 16 check-in — 5kg down, reflux manageable, one thing confusing me — and the rest is context. The relevant figures are week 16 and 5kg, and they come from the same log I have kept the whole time. Week 95 was the first time the scale moved after a five-week stall. I changed nothing…

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15 comments, started 2 years ago
u/halima_boateng722 points·2 years ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

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u/britt_okwuosa536 points·2 years ago

Appetite effect for me is flat across seven days.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

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u/tove_vasquez153 points·2 years ago

Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.

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u/elin_varga213 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

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u/quiet_moderatormod117 points·2 years ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

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u/ferran_mensah71 points·2 years ago

Push back: "gentler than sema" is a population statement.

tove_vasquez is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

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u/b12_baseline25 points·2 years ago

tove_vasquez is right that the two molecules are not interchangeable.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

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u/throwaway_titration-31 points·2 years ago

15kg over 76 weeks, never went past 10mg, and muscle cramps stayed mild the whole way. Posting because the loud threads are all 15mg.

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u/sten_palaciosOP365 points·2 years ago

What step are you on and how long have you been there?

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u/piotr_nascimento145 points·2 years ago

This matches mine. Milder fatigue than I expected, and what there was settled inside a fortnight of each step.

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u/sten_palaciosOP72 points·2 years ago

What is the waist doing? That is usually the number still moving during a scale stall.

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u/nz_unfunded21 points·2 years ago

switching from sema is not a dose conversion, there is no clean equivalence

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u/incretin_ivypharmacology15 points·2 years ago

Correction to my own post above — I said 12.5mg and I have been on 15mg since the spring. Same argument, wrong number.

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u/rania_marchand220 points·2 years ago

Pen or vial? The step sizes available differ and it changes this answer.

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u/emil_okwuosa181 points·2 years ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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