GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Archived. This submission is more than a year old. Votes and new comments are closed, and some of the advice in it may have been superseded — check the community wiki for the current version.
7k
c/tirzepatide·posted 2 years ago by u/sten_palacios

week 16 check-in — 5kg down, reflux manageable, one thing confusing me

Question Cold Box ×7 Long Haul ×3 Clean Column ×3

Six-word version is the title — week 16 check-in — 5kg down, reflux manageable, one thing confusing me — and the rest is context.

The relevant figures are week 16 and 5kg, and they come from the same log I have kept the whole time.

Week 95 was the first time the scale moved after a five-week stall. I changed nothing in that window.

Came off sema and onto tirz with a two-week gap. The first month was flat and I assumed I had made a mistake. Month two it moved.

Not medical advice, obviously, and nothing here is approved for human use. One person with a spreadsheet.

7,393 up / 429 down95% upvoted53 commentsid 1407sc10 Dec 2023

53 comments

20 in this archive, depth 6

best — the order this archive was captured in

u/emil_barros982 points·2 years ago

The distribution matters more than the mean. In the trial population the interquartile spread was wide enough that two honest people can have completely different runs on the same arm.

replysharereportpermalink
u/georgi_chowdhury807 points·2 years ago

That percentage is body weight change, not body fat. Different measurement, and the distinction gets lost every time.

replysharereportpermalink
u/sten_palaciosOP451 points·2 years ago·edited

Which week did the appetite change actually land for you?

replysharereportpermalink
u/gentle_correctionnice about it138 points·2 years ago

if 7.5 is working, 10 is not automatically better

replysharereportpermalink
u/incretin_ivyMOD748 points·2 years ago

Trial identifiers corrected in the title. SURMOUNT and SURPASS are different programmes.

replysharereportpermalink
u/halima_boateng722 points·2 years ago

Appetite effect for me is flat across seven days. On sema it was a wave. Same person, different molecule.

replysharereportpermalink
u/britt_okwuosa536 points·2 years ago

Appetite effect for me is flat across seven days.

This. The step interval is a floor, and reading it as a timetable is the most expensive mistake in the thread.

replysharereportpermalink
u/tove_vasquez153 points·2 years ago

Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.

replysharereportpermalink
u/elin_varga213 points·2 years ago

Small fix: SURMOUNT is the obesity programme, SURPASS is the type-2 programme. They are different endpoints and the numbers do not transfer.

replysharereportpermalink
u/quiet_moderatormod117 points·2 years ago

dual agonist, so the GIP arm is doing something the sema threads will not tell you about

replysharereportpermalink
u/ferran_mensah71 points·2 years ago

Push back: "gentler than sema" is a population statement.

tove_vasquez is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.

replysharereportpermalink
u/b12_baseline25 points·2 years ago

tove_vasquez is right that the two molecules are not interchangeable.

Not sure about this bit. The GIP arm being real does not tell you that it is what caused your particular week.

replysharereportpermalink
u/throwaway_titration-31 points·2 years ago

15kg over 76 weeks, never went past 10mg, and muscle cramps stayed mild the whole way. Posting because the loud threads are all 15mg.

replysharereportpermalink
u/sten_palaciosOP365 points·2 years ago

What step are you on and how long have you been there?

replysharereportpermalink
u/piotr_nascimento145 points·2 years ago

This matches mine. Milder fatigue than I expected, and what there was settled inside a fortnight of each step.

replysharereportpermalink
u/sten_palaciosOP72 points·2 years ago

What is the waist doing? That is usually the number still moving during a scale stall.

replysharereportpermalink
u/nz_unfunded21 points·2 years ago

switching from sema is not a dose conversion, there is no clean equivalence

replysharereportpermalink
u/incretin_ivypharmacology15 points·2 years ago

Correction to my own post above — I said 12.5mg and I have been on 15mg since the spring. Same argument, wrong number.

replysharereportpermalink
u/rania_marchand220 points·2 years ago

Pen or vial? The step sizes available differ and it changes this answer.

replysharereportpermalink
u/emil_okwuosa181 points·2 years ago

Right. And the sema-to-tirz "conversion" people post is invented. There is no published equivalence.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Moderators
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.