[Question] tirzepatide — what am I missing here
tirzepatide — what am I missing here. If this has been answered properly somewhere, link me and I will delete. Went 10 to 12.5 on the calendar and had the worst fortnight of the whole run. Dropped back to 10 and everything settled. Came off sema and onto tirz with a two-week gap. The first month was flat and I…
SURMOUNT-1 ran 72 weeks with the top arm around 21% mean body weight change. SURPASS is the diabetes programme and reports glycaemic endpoints, so quoting the two interchangeably is a category error.
Push back: "gentler than sema" is a population statement. Plenty of people on this board have the opposite experience and they are not doing it wrong.
The four-week interval in the label is a minimum. Nothing about the pharmacology requires you to step on schedule, and the trials stepped on a calendar because trials have to.
The thing nobody warned me about was how much of this is logistics — storing it, remembering it, the same day every week.
Push back: "gentler than sema" is a population statement.
bastian_eriksen is right that the two molecules are not interchangeable. There is no published conversion and the ones circulating are invented.
the four-week step schedule is the label, not folklore